G6PD and infection: For settings with high transmission intensity, since there are higher rates of infections, symptomatic or not, and as a result higher rates of seropositivity, we observe higher numbers of G6PD tests and treatments required for PvSeroTAT in São Gabriel da Cachoeira (Supplementary Fig. S4) compared to peri-urban Manaus (Supplementary Fig. S3) and to Itaituba (Fig. 3).