Glucose intolerance mediated by increased hepatic gluconeogenesis. Rapamycin induces the upregulation of gluconeogenic genes, PEPCK and G6Pase, transcriptional co-activator PGC1-a, and enhances the nuclear recruitment of FoxO1, CRTC2, and CREB. The gene discussed is CRTC2; the disease is Glucose intolerance.