We can summarize our recent study as follows: (1) we confirmed that itch sensation was significantly associated with the cutaneous disease activity of DM determined by CDASI; (2) the mRNA expressions and immunohistochemistry analysis of the majority of examined pruritogenic mediators and receptors were not different in the lesional and non-lesional skin samples; and (3) TNF-α and IL-6 might contribute to the development of itch in patients with DM. The gene discussed is TNF; the disease is diabetes mellitus.