The top five pathways with the lowest FDR were ECM-receptor interaction (KEGG pathway: hsa04512, count=8, FDR=1.2E-10), focal adhesion (KEGG pathway: hsa04510, count=8, FDR=2.9E-8), human papillomavirus infection (KEGG pathway: hsa05165, count=8, FDR=8.6E-7), PI3K-Akt signaling pathway (KEGG pathway: hsa04151, count=8, FDR=1.1E-6), and phagosome (KEGG pathway: hsa04145, count=6, FDR=2.3E-6). The gene discussed is AKT1; the disease is human papilloma virus infection.