LAMP1 and chronic myelogenous leukemia, BCR-ABL1 positive: Our data are consistent with findings reported in previous studies that showed that LAMP1 is one of the most important 1,6-branched polylactosamine-carrier proteins in chronic myelogenous leukemia cells.36) A decrease in the polylactosamine structure, which protects LAMP1 from the action of lysosomal hydrolases, in BC cells may result in the degradation of LAMP1 and the concomitant destabilization of lysosomal function.37) As shown in Fig. 6, lysosomes containing LAMP1 predominantly accumulated in the cytoplasm around the nucleus.