The PI3K/AKT/mTOR signal transduction pathway acts as an essential part in tumor development and progression, which is frequently dysregulated in MM, pancreatic cancer, gastrointestinal stromal tumors, etc. The activated PI3K/AKT signal transduction pathway promotes tumor cell migration, proliferation, and drug resistance via its downstream effectors and is therefore a potential anti-tumor therapeutic target. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.