IDH2 and central nervous system cancer: Notably, isocitrate dehydrogenase (IDH) gene mutation can modify cell metabolism and may be involved in the occurrence and development of tumors.4 IDH1/2 gene mutation is the most common metabolic enzyme gene mutation, is more common in some subtypes of acute myeloid leukemia and glioma, and is related to the occurrence, development and prognosis of glioma.5,6 Telomerase reverse transcriptase (TERT) promoter region mutation is a point mutation in the core sequence of the TERT promoter region.