NFKB1 and central nervous system cancer: TERT promoter mutation can affect the NF-κB signaling pathway which plays a regulatory role leading to the release of inflammatory mediators and aggravating tumor progression, resulting in further damage to the body, possibly increasing the risk of death.21 In addition, Cox multivariate analysis showed that total tumor resection, preoperative KPS score ≥60, postoperative radiotherapy and chemotherapy, and IDH1/2 gene mutation were associated with better postoperative survival of patients with glioma, while TERT promoter mutation was associated with poor postoperative survival.