By analyzing the factors that affect the survival of patients with brain glioma after surgery, this study concluded that mutations in IDH1/2 gene and TERT promoter have an impact on the prognosis of patients, but the specific mechanism by which they have a good or bad effect on the prognosis of patients is not yet very clear, just to guess that it may be related to the body’s antioxidant stress, and lay a certain foundation for further research on the mechanism. This evidence concerns the gene TERT and brain glioma.