EGFR and neoplasm: At present, studies have investigated the efficacy of EGFR-TKI combined with chemotherapy from the perspective of overall survival, but there are few reports comparing EGFR-TKI targeted combined chemotherapy with EGFR-TKI or chemotherapy alone in terms of immune function, tumor markers and oxidative stress in stage-IV lung adenocarcinoma.16-18 Therefore, this study mainly discussed the effects of EGFR-TKI targeted combined chemotherapy on immune function, tumor markers and oxidative stress level of stage-IV lung adenocarcinoma patients.