This study aimed to study the serum levels of IGF-1 in both RF +ive and RF –ive RA patients as well as healthy controls, and to observe the frequency with which 192-bp allele of IGF-1 appeared in the study groups, its relationship to serum IGF-1 levels and also if it bore any relation to disease severity. This evidence concerns the gene IGF1 and rheumatoid arthritis.