It has been found that laboratory indicators such as uric acid, the renin-angiotensin aldosterone system, angiogenic factors and proinflammatory markers of endothelial dysfunction have changed in women with chronic hypertension, but none of these biomarkers have been proved to be useful in the screening and diagnosis of superimposed preeclampsia (Kametas et al., 2022). Here, REN is linked to endothelial dysfunction.