For instance, mutations in the N-terminal domain can lead to hereditary spastic paraplegia (SPG10) or Charcot–Marie-Tooth type 2 hereditary neuropathy (CTM2) (Reid et al., 2002; Liu et al., 2014), and the lack of KIF5A expression can lead to accumulations of downstream proteins, which are associated with neurodegeneration in patients with multiple sclerosis (MS) (Hares et al., 2021). The gene discussed is KIF5A; the disease is hereditary spastic paraplegia.