CFAP410 and amyotrophic lateral sclerosis: Through whole-genome-sequencing in a great number of (12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort) ALS patients, Van Rheenen et al. (2016) identified C21ORF2 (also known as CFAP410) as a gene associated with ALS risk.