We hypothesized that (1) PA patients have significantly decreased behavioral and ERP results in attention networks; (2) Attention networks might be exhibited hemispheric asymmetry in two groups; (3) The pattern of hemispheric asymmetry in PA patients might be different from that in HCs; and (4) The serum prolactin (PRL) level may impair attention networks in patients with pituitary adenoma. This evidence concerns the gene PRL and pituitary gland adenoma.