Interestingly, C9ORF72 deficiency has been shown to increase ROS levels in the iPSC-derived motor neurons from multiple ALS/FTLD patients with C9ORF72 mutations56 and in C9orf72−/− bone marrow-derived primary macrophages after zymosan ingestion.11 Here, C9orf72 is linked to amyotrophic lateral sclerosis.