Gene set enrichment analysis (GSEA) in D8 P1 cells revealed enrichment in Kyoto Encyclopedia of Genes and Genomes (KEGG) categories related to T cell receptor (TCR) and Toll-like receptor (TLR) signaling pathways (Figure 5E), suggesting that SOX18 overexpression has a major effect on establishing T lymphoid transcriptional program in the D8 P1 multipotent HPs arising from HE. This evidence concerns the gene SOX18 and hereditary elliptocytosis.