The groups included a cluster of transcription factors important in the biology of luminal bladder cancer (GATA3 and FOXA1), elements of the cohesin and mediator complexes involved in regulation of transcription and chromatin structure maintenance, the aryl hydrocarbon receptor involved in the detoxification from xenobiotic chemicals, and the KEAP1/CUL3 E3-ubiquitin ligase complex, a key player in the oxidative stress response. Here, CUL3 is linked to urinary bladder cancer.