Our data are supported by a recent study that performed GATA3 ChIP-Seq on the luminal bladder cancer cell line RT4 and identified GATA3 binding to enhancer regions of PPARG. 63Consistent with GATA3 regulating PPARG by binding DNA at distal sites, identification of components of the mediator and cohesin complexes as hits in our screen suggests that chromatin looping and binding of transcription factors at distal enhancer sites are involved in the regulation of PPARG. 64Alternatively, GATA3 may indirectly regulate PPARγ by altering cell differentiation or luminal phenotypes. Here, PPARG is linked to urinary bladder cancer.