Importantly, GADD45B knockdown not only resulted in the highest proliferation increase in HCC cells (Figure 5C) but also reversed ZY0511‐induced proliferation inhibition of HepG2 cells (Figure 5D,E), suggesting that GADD45B is an important downstream molecule of LSD1 and plays a critical role in ZY0511 efficiency. The gene discussed is GADD45B; the disease is hepatocellular carcinoma.