As a downstream effector of RAS, RAL GTPase mediates various cellular activities to regulate tumor invasion, proliferation, and resistance to cell death, which are executed by the RAL effectors, including RALBP1, Sec5, Exo8426, Filamin, PLD1, and ZONAB.215, 216, 217, 218, 219, 220, 221. This evidence concerns the gene RALA and neoplasm.