ATP2B4 and type 2 diabetes mellitus: Scarce information is available regarding the mechanisms by which T2DM affects PMCA in VSMCs; however, our results resemble those reported by El-Najjar et al., who showed that PMCA activity in rat aortic VSMCs exposed to high extracellular glucose is enhanced due to the increase in PMCA4 expression (El-Najjar et al., 2017).