Preliminary evidence showed that TRPC6 protein was upregulated in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats (Mita et al., 2010), whereas TRPC3 protein expression was increased in platelets of patients affected by T2DM (Zbidi et al., 2009). This evidence concerns the gene TRPC3 and type 2 diabetes mellitus.