Along the same lines, modulation of the cytotoxic effects of the SOD1 mutation in glial cells was suggested to prevent MN death in the context of ALS (Pramatarova et al., 2001; Ambrożkiewicz et al., 2022; Perez-Gonzalez et al., 2022). Here, SOD1 is linked to amyotrophic lateral sclerosis.