SOD1 and amyotrophic lateral sclerosis: ALS-linked mutations, responsible for fALS forms, have been identified in more than 30 genes, including SOD1 (which accounts for up to 12%–23% of fALS) (Bosco et al., 2010), TDP-43 (Sreedharan et al., 2008), FUS (Vance et al., 2009), and C9ORF72 (Smith et al., 2013).