Although the lifestyle and the commonly prescribed drugs of pwCF could play a role in protecting against severe SARS-CoV-2 infection, cellular and molecular mechanisms may be important factors in the lower infection rates and symptoms reported in pwCF (Table 1), suggesting that CFTR protein function and expression are actively involved in both ACE2-mediated virus uptake and SARS-CoV-2 viral particle replication once the virus has entered the host cells. Here, CFTR is linked to infection.