CFTR and COVID-19: It has also been demonstrated in vitro that the recovery of CFTR expression and function by CFTR modulators treatment is associated with a sudden increase in viral replication (Lotti et al., 2022), in contrast to clinical observation reporting a less severe outcome of COVID-19 in pwCF in case of CFTR modulators therapy (Bain et al., 2021; Simonson et al., 2022).