Moreover, it was observed that mutated CFTR channel could induce mislocalization of ACE2 into the ER and that, depending on the pattern of ACE2 expression, SARS-CoV-2 S protein induced high levels of IL-6 in healthy primary cells, but a very weak response in primary CF cells (Bezzerri et al., 2023). This evidence concerns the gene CFTR and cystic fibrosis.