The TRIM family consists of over 70 members, and several TRIM proteins, such as TRIM8, 13,19,24,27,29,31, 32, 33, 40,59 and 69, have recently been verified to be involved in oncogenesis or tumor progression by regulating specific signal pathways, such as p53, RARα, NF-κB, in various kinds of cancers (Hatakeyama 2011). The gene discussed is TRAT1; the disease is cancer.