In accordance with our findings, an additional HDGC family has been reported in the literature, bearing a 275 kb CDH1 (exon 7) and TANGO6 (full gene) deletion, with four patients in four consecutive generations affected by gastric cancer, from which two were confirmed with signet ring cell carcinoma at ages 30 and 34 years old [44]. This evidence concerns the gene DSG2 and signet ring cell carcinoma.