CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome: In CDH1-associated HDGC, the cumulative DGC incidence ranges from 42 to 72% in males [10, 11], and from 33 to 55% in females, whilst the risk of LBC ranges from 39 to 55% in females, by 80 years of age [10–13].