Increased proliferation associated with MAPK cascade [67, 68] and decreased DNA damage response mediated by p53 signalling [69–71], also found in cells bearing the family CNV, may hint to more aggressive DGC, than the commonly described for HDGC patients bearing CDH1-coding variants, who generally die by dissemination to the peritoneum [43]. This evidence concerns the gene CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome.