MCAM and cerebral cavernous malformation: The marker CD146/MUC18 (Fig. 3a–i) showed an overexpression in the early passage (p.2) of all three different culture media and then gradually showed a significant decrease in mSG-SCs cultures in CCM (p.6: 74.2%, p.10: 24.3%), It has also been observed a moderate downregulation in StemMacs (p.6: 89.5%, p.10: 68.7% of cells), while StemPro maintained high overexpression levels (p.6: 91.2%, p.10: 88.1% of cells).