While investigating the relationship between rs58349661 and previously studied genetic variants, we found that this locus is close to, but not in strong LD (R2 = 0.002 to 0.162) with genetic variants previously associated with colorectal cancer in FMN1 (rs16959063, rs17816465), GREM1 (rs10318, rs1919364), and SCG5 (rs16969681, rs4779584; refs. 8, 28, 29). Here, GREM1 is linked to colorectal cancer.