Among the ∼200 SNPs associated with colorectal cancer in GWAS, an increasing number of independent loci have been located within the broader SCG5-GREM1-FMN1 region (rs17816465, rs10318, rs1919364, rs16969681, and rs4779584; refs. 8, 30, 31). This evidence concerns the gene GREM1 and colorectal cancer.