Males are more likely than girls to develop type 1 diabetes, especially in high-risk countries.6 High concordance in the development of type 1 diabetes (about 42%) and CD (approximately 75%-90%) in monozygotic twins is the most important evidence demonstrating the role of genes in the etiology of diabetes mellitus and CD.4 The diagnosis of CD in children can be established without biopsy using high levels of tissue transglutaminase autoantibodies, endomysial autoantibodies, and CD-type HLA genotypes.4,15. This evidence concerns the gene TGM2 and type 1 diabetes mellitus.