Much greater enhancement was observed as we further increased the density of randomly distributed binding sites:~29,000 maximum fold enhancement at the ρ of 58.8 (Figure 4—figure supplement 1), which roughly corresponds to two-hundredths of the density of the HER2 receptor on HER2-overexpressing breast cancer cells (Peckys et al., 2019). Here, ERBB2 is linked to breast cancer.