Immunosuppression is another feature of immune imbalance in sepsis, which manifests as immune cell anergy (CD4+ T lymphocytes, CD8+ T lymphocytes, B lymphocytes, and DC exhaustion) and a decreased ability to fight primary bacterial infections; this condition usually develops a few days after infection due to a highly inflammatory response that may cause further secondary infections and worsen disease progression.54 Here, CD8A is linked to infection.