Myo‐inositol oxygenase accelerated inflammation in the model of infection‐induced cardiac dysfunction, which may be, at least in part, attributable to the induction of NLR family pyrin domain containing 3 (NLRP3) inflammasome through the inhibition of NLRP3 degradation in infection‐induced cardiac dysfunction. The gene discussed is NLRP3; the disease is infection.