Furthermore, Tim‐3 expression on CD3+T cells, CD4+T cells, and CD8+T cells was significantly different among the three Binet stage groups of CLL patients; the Tim‐3 expression on T cells became more abundant in the later Binet stage in the CLL group (p < .05, p < .01; Figure 2C–E and Table 3). This evidence concerns the gene CD4 and B-cell chronic lymphocytic leukemia.