The expressions of genes IAPP, Slc30a8, Scg2, Chga, and Chgb were significantly reduced, which can protect islet B cells from apoptosis and can also change the insulin secretion defect caused by the inflammatory environment of pancreatic islets, thus improving the function of islet B cells and reducing the risk of TB patients complicated with T2DM.39, 97. The gene discussed is SCG2; the disease is tuberculosis.