AKT1 and tuberculosis: After the immunotherapy with ag85a/b DNA vaccine IM or EP in the mice infected with MTB, the anabolism, developmental process, and immune response‐related pathways (such as ECM receiver interaction, Focal induction, PI3K Akt signaling pathway, Rap1 signaling pathway, etc.)were enhanced, the transcriptional levels of the surfactant genes were significantly upregulated, the number of MTB colonies in the lung was reduced, and the lung lesions in mice were alleviated, which proved that pulmonary surfactants have a potential role in the host‐directed treatment of TB.107