Both our study and GSE89403 found that MTB infection significantly reduced the expression of Sftpd and Cldn5, but the treatment of ag85a/b DNA vaccine and GSE89403 significantly increased the expression of Sftpd and Cldn5, proving that Sftpd and Cldn5 can also become the targets for TB treatment. This evidence concerns the gene CLDN5 and tuberculosis.