Moreover, VPS72 overexpression had a significant correlation to poor prognosis, higher Pathological stage, histologic grade, T stage, AFP level, postoperative recurrence, vascular infiltration, and the degree of adjacent hepatic tissue inflammation in HCC patients; moreover, VPS72 expression in ONCOMINE database was associated with higher tumor grades, patients with satellites, HCV positive, and vascular invasion. Here, AFP is linked to hepatocellular carcinoma.