The relation between VPSs expression and patient OS was further analyzed in TCGA and ICGC databases, revealing that based on Univariate analysis, the higher VPS16/25/26A/29/33A/33B/37A/37C/54/72 mRNA expression levels were correlated to shorter OS in HCC (Figure 3A,B and Supporting Information: Figure S2), AS well as T stage, pathological stage, and tumor status, were correlated to shorter OS in HCC (Figure 3C). This evidence concerns the gene VPS16 and hepatocellular carcinoma.