In our study, through the analysis of TCGA and ICGC databases, VPS72 is overexpressed in HCC tissues, which has a correlation to a poor prognosis in HCC patients and may serve as an independent risk factor for HCC, and VPS72 is also highly expressed in HCC tissues in GEO database and multiple ONCOMINE data sets. The gene discussed is VPS72; the disease is hepatocellular carcinoma.