CKD-mineral bone disorder (MBD) is a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of abnormalities of calcium, phosphate, parathyroid hormone (PTH), or vitamin D metabolism, abnormalities in bone turnover, mineralization, volume, linear growth, or strength and vascular or other soft-tissue calcification.62 This evidence concerns the gene PTH and chronic kidney disease.