CKD-mineral bone disorder (MBD) is a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of abnormalities of calcium, phosphate, parathyroid hormone (PTH), or vitamin D metabolism, abnormalities in bone turnover, mineralization, volume, linear growth, or strength and vascular or other soft-tissue calcification.62 The gene discussed is PTH; the disease is Marchiafava-Bignami disease.