Crossing TRE‐myc mice with a transgenic line of LAP‐tetracycline transactivator (tTA) to study the effects of myc inactivation, LAP‐tTA/tet‐off myc conditional transgenic mice overexpressing myc in adult mice reproducibly induced HCC, revealing the pluripotent capacity of existing in a state of tumor dormancy.92 This evidence concerns the gene CEBPB and hepatocellular carcinoma.