On this basis, the introduction of p53 and phosphatase and tensin homolog deleted from chromosome 10 (Pten) dual mutation into HBV Alb‐1 mice to form HCC mice after 8 months provides a fast and convenient transgenic system with HBV infection characteristics, which is suitable for mechanism and drug screening of HBV‐related HCC.89 This evidence concerns the gene PTEN and hepatocellular carcinoma.