Furthermore, a modest increase in NE-DNA and MPO-DNA levels was observed in COVID-19 ICU patients compared to non-COVID-19 ICU (p = 0.04 and p = 0.02 respectively) patients (Figure 1b,c), indicating a more profound increase in NET levels in critically ill patients due to COVID-19 infections as compared to other infections requiring invasive mechanical ventilation. Here, MPO is linked to infection.