Ubiquitin phosphorylation by the mitochondrial proteinkinase PTEN-inducedkinase 1 (PINK1), upon mitochondrial depolarization, is an importantintermediate step in the recycling of damaged mitochondria via mitophagy.As mutations in PINK1 can cause early-onset Parkinson’s disease(PD), there has been a growing interest in small-molecule activatorsof PINK1-mediated mitophagy as potential PD treatments. This evidence concerns the gene PINK1 and Parkinson disease.