CD274 and renal pelvis/ureter urothelial carcinoma: In metastatic UTUC, chemotherapy and radical nephrectomy are protective factors for higher survival, while patients with liver metastases often predict a poorer prognosis, although platinum-based combination chemotherapy is currently used as a first-line treatment option and immunotherapy with PD-1/PD-L1 pathway inhibition has been shown to be safe and effective in the systemic management of metastatic UTUC [35, 37–39].