At 28 days, we additionally observed increased expression of the pan-reactive marker Cxcl10 and the LPS-specific marker Amigo2. Collectively, these data suggest that microglial and astrocytic gene expression phenotypes in experimental HE resemble those in other neuroinflammatory disorders despite the unique features of hyperammonemia and cholestasis. The gene discussed is CXCL10; the disease is Hyperammonemia.