Clinical analysis revealed that COVID-19 patients infected by Δ382 AS had higher concentrations of IFN-γ and lower concentrations of the chemokines IP-10 (CXCL10), MCP-1 (CCL2), and MIP-1β (CCL4), and lower odds of developing hypoxia compared to patients infected by the WT virus [11], indicating the potential pathogenesis of ORF8. The gene discussed is CXCL10; the disease is COVID-19.