CLSPN and cervical carcinoma: Moreover, PLK1 is responsible for orchestrating the degradation of Claspin required for DNA damage checkpoint recovery, and its activation is tightly regulated by the phosphorylation status of Aurora A. In the context of HPV-induced cervical cancer, it has been observed that cells expressing HPV-16 E7 exhibit elevated levels of both Aurora A and PLK1, leading to the possibility of dysregulated regulation of these kinases and cell cycle checkpoints.