RNA-Seq data [31] further revealed that the downstream target of the IGF2BP2-IGF2 axis, IGF1R, was significantly increased in metastatic tissues (Fig. 2A), whereas the inhibitor of the PI3K-AKT pathway PTEN was decreased in both primary and metastatic tumor tissue (Fig. 2B). The gene discussed is IGF2; the disease is metastatic neoplasm.