The HR (95% CI) for diabetes connection with the ALT/HDL-C ratio was 1.05 (1.04–1.05) in Model I. After adjusting for gender, ethanol consumption, BMI, habit of exercise, smoking status, SBP and age, the HR (95% CI) was 1.03 (1.02–1.04) in Model II. The gene discussed is GPT; the disease is diabetes mellitus.