Immunotherapy for GI cancers includes checkpoint inhibitors (PD-1, PD-L1 and CTLA-4), vaccine therapies (peptide, protein, whole tumor cells, or dendritic cell-based vaccines), cytokines (interferon-γ, interleukin-2, IL-10, or GM-CSF) and adoptive T cell transfer [2]. This evidence concerns the gene CSF2 and neoplasm.