DICER1 and brain sarcoma: Molecular study of the brain sarcoma revealed somatic pathogenic mutations in NF1 (c.4950del, p.Y1650* and c.6756+3A>C) and TP53 (c.523C>G, p.R175G), as well as a somatic DICER1 hotspot mutation (c.5439G>T p.E1813D) (Fig. 1l).