Despite metformin therapy, a significant increase in serum androgen and tumour marker levels were detected (AFP = 4.5 ng/mL, β-HCG < 2 mIU/mL, CA-125 = 26 IU/mL, CA-15–3 = 31.5 U/mL, CA-19–9 < 2.00 U/mL). This evidence concerns the gene AFP and neoplasm.