TARDBP and amyotrophic lateral sclerosis: We used sarkosyl-insoluble TDP-43 protein extract from three different ALS/FTLD-TDP cases that presented distinctive morphological phospho-positive TDP-43 aggregates in the frontal cortex and differential TDP-43 band patterns specifically related to the CTFs (Extended Data Fig. 8a,b and Supplementary Table 3).