Both the DAAO-TGTie2 and DAAO-TGCdh5 mouse lines have expression of the DAAO transgene in vascular endothelial cells (Supplementary Fig. 6), but only the DAAO-TGCdh5 line has expression in DRG (Supplementary Fig. 7), and the DAAO-TGCdh5 line alone shows neurodegeneration and cardiac hypertrophy. Here, DAO is linked to cardiac hypertrophy.