When DAAO-TGTie2 mice are fed D-alanine, we saw no ataxia whatsoever, and we found that there was no expression of the Tie2-driven transgene in DRG neurons (Supplementary Fig. 7) despite robust transgene expression of the transgene in mesenteric (Supplementary Fig. 6b, c) and cardiac (Supplementary Fig. 6e) blood vessels. The gene discussed is DAO; the disease is Ataxia.