Interestingly, while the baseline association was confined to the mesial temporal cortex, the longitudinal tau–PET accumulation as a function of Aβ/Ast presented initial tau spread over the neocortex in Braak III–IV regions (32.5% of Braak III and 30% of Braak IV areas; Fig. 3c), further supporting the notion that these individuals are following a tau accumulation pathway consistent with AD progression26. This evidence concerns the gene MAPT and Alzheimer disease.