In the hypoxia and drug resistance of tumor treatment, Gong et al.59 found the knockdown of kruppel-like factor 5, which promoted hypoxia-induced cell apoptosis by directly regulating HIF-1α expression in hypoxia-mediated cisplatin-resistant non-small cell lung cancer (NSCLC) cells. Here, HIF1A is linked to non-small cell lung carcinoma.