As the HIF-1α involved in various hypoxia-related diseases, Jin, et al. demonstrated FTH1 suppressed the transcriptional activity of HIF-1α in HCT116 cells of human colorectal cancer, and downregulated the expression of HIF-1 target genes including VEGF, CA9, and GLUT148. The gene discussed is FTH1; the disease is colorectal cancer.