GLS and hepatocellular carcinoma: To investigate whether BAIAP2L2 is implicated in cuprotosis, we screened two BAIAP2L2-regulated cuprotosis-related genes (GLS and PDHB) by taking the intersections of 8,646 BAIAP2L2-regulated DEGs and 10 cuproptosis-related genes in HCC (Fig. 6A).