We analyzed 15 hub genes (SNRPA, NCBP2, EIF2S2, NOP58, PES1, PA2G4, RAN, UBE2S, PHC2, EZH2, KIFC1, CDC20, KIF2C, E2F2, and PLK1) coexpressed with BAIAP2L2 in HCC to investigate the potential function of BAIAP2L2 in HCC. This evidence concerns the gene PLK1 and hepatocellular carcinoma.