CLCN6 and cardiovascular disorder: For example, CLCN6 (rs1023252, SIFT score = 0, deleterious_low_confidence) and C1orf167 (rs61773952, SIFT score = 0.01, deleterious; PolyPhen-2 score = 0.974, probably damaging) could affect protein function in cluster 9, which has been implicated in cardiovascular disease.13 The genes in cluster 9 were enriched for positive regulation of the apoptotic process [GO: 0043065].