We performed cumulative risk assessments for each biomarker and identified 12 high-risk biomarkers for stroke recurrence in the population, including the inflammatory factors interleukin-6 (IL-6), Lp-PLA2-activity, high-sensitivity C-reactive protein (hs-CRP), neutrophils, chitinase-3-like protein 1 (YKL-40), and basophils; D-dimer; fasting plasma glucose (FPG); the gut microbial metabolites choline, butyrobetaine, and trimethyllysine (TML); renal function index (UMA); and the four low-risk biomarkers albumin, apolipoprotein AII, folic acid, and N,N,N-trimethyl-5-aminovaleric acid (TMAVA). Here, IL6 is linked to Stroke.