Kidney disease is a major risk factor for cerebrovascular disease.26 Additionally, renal insufficiency can lead to inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism.27,28 Subpopulations identified by biomarkers of renal function, such as UMA, cystatin C, and creatinine, had a significantly high risk of stroke recurrence and mortality. The gene discussed is CST3; the disease is cerebrovascular disorder.