Some tumors prefer to use exogenous cholesterol at the expense of the more time-consuming and energy-consuming de novo cholesterol synthesis [155,156], whereas other tumors rely entirely on LDLR-mediated exogenous cholesterol uptake due to defects in the cholesterol biosynthesis pathway [157], highlighting the importance of exogenous cholesterol uptake for tumor cell survival. Here, LDLR is linked to neoplasm.