ALB and hepatocellular carcinoma: Peretinoin (4,5-didehydroGGA [XII]), an acyclic retinoid, was observed to inhibit cell proliferation, upregulate albumin (ALB) gene expression, downregulate α-fetoprotein (AFP) gene expression, and induce differentiation into hepatocytes when added to a culture system of human hepatoma-derived cell lines (29).